Anne Dinning was born in New York, New York, United States. Anne Dinning has helped run D.E. Shaw, one of the most successful quantitative hedge fund firms on Wall Street, for nearly two decades. The Seattle native joined billionaire David Shaw's firm in 1990, after receiving her Ph.D. in computer science from New York University. She quickly rose through the ranks, overseeing much of the firm's hedge fund activities by 1995, before briefly retiring in 1999. Three years later, Dinning returned as Shaw handed over the day-to-day management of his fund to an executive committee. After 15 years on the executive committee, Dinning moved into a senior leadership role as a managing director in 2017.